Chris­t­ian Haass is a German Biochemist and known for his work on the cell biology of neurode­gen­er­a­tive diseases.

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Chris­t­ian Haass, Profes­sor of Metabolic Biochem­istry at LMU Munich and spokesper­son for the DZNE Munich, is known for his ground­break­ing research rein Alzheimer's disease. His work focuses on the molec­u­lar and cellu­lar mecha­nisms of this disease in order to gain funda­men­tal insights into its devel­op­ment.

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  Very recently he also investigated the role of microglia and inflammation hinein neurodegenerative disorders.  This work Leuchtdiode to the spectacular finding that microglial phagocytosis may Beryllium impaired late during neurodegeneration and opened up a completely unexpected road towards new therapeutic developments for patients already developing disease symptoms.  This work resulted in the identification of TREM2 as a CSF marker for microglial activity.  In a unique cohort of subjects with autosomal dominant AD, CSF sTREM2 was abnormally increased 5 years before the expected onset of symptoms. This will not only greatly facilitate research on inflammatory disease overarching mechanisms, but may also provide a very valuable therapeutic marker.

We are using interdisciplinary approaches ranging from biophysics, biochemistry and cellular and molecular biology to hinein vivo models and life imaging.

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